Before taking secnidazole, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as tinidazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain rare genetic disorder (Cockayne syndrome).

If you are taking this medication to treat trichomoniasis, avoid having sex until you and your sex partner(s) have completed treatment and do not have any symptoms (such as vaginal discharge, pain when urinating). Many people with trichomoniasis do not have any symptoms, so it is important to treat all sex partners at the same time to avoid getting infected again.

Secnidazole may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using secnidazole before having any immunizations/vaccinations.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding is not recommended while using this drug and for 4 days after taking this drug. Consult your doctor before breastfeeding.