Take this medication by mouth as directed by your doctor, usually twice daily. Take it with food, milk, or antacids to reduce stomach upset. To prevent kidney stones, it is best to drink a full glass of water (8 ounces or 240 milliliters) with each dose and at least another 8 glasses a day while taking this drug. If your doctor has directed you to restrict your fluid intake, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acidity in your urine (such as by avoiding large amounts of ascorbic acid/vitamin C) to prevent kidney stones. Your doctor may direct you to take other medications (such as sodium bicarbonate, citrate) to make your urine less acidic.

Dosage is based on your condition and response to treatment. Your doctor may direct you to take a low dose at first, then adjust your dose based on uric acid levels and your gout symptoms. After you have been symptom-free for several months and your uric acid levels are normal, your doctor may lower your dose to the lowest effective dose. Follow your doctor's directions carefully.

If you are also taking cholestyramine, take sulfinpyrazone at least 1 hour before or 4-6 hours after cholestyramine. Consult your doctor for more details.

Sulfinpyrazone should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication. You may experience an increase in the number of gout attacks for several months after starting this medicine while the body removes extra uric acid. If you have a gout attack while taking sulfinpyrazone, keep taking it along with your medications for gout pain.

Sulfinpyrazone is not a pain reliever. To relieve pain from gout, continue to take your medicines prescribed for pain from gout attacks (such as colchicine, ibuprofen, indomethacin) as directed by your doctor.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Tell your doctor if your condition lasts or gets worse.