This medication is given by injection into a vein as directed by your doctor. After first receiving this medication in a hemophilia treatment center or hospital, some patients may be able to give it to themselves at home. If your doctor directs you to give this medication at home, read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. Learn all preparation and usage instructions in the product package. Learn how to store and discard medical supplies safely. If you have any questions, ask your health care professional.

Depending on your factor VIII blood level and medical condition, your doctor may direct you to also give factor VIII with your first dose of von Willebrand factor for each bleeding episode. Ask your doctor for more details.

If the medication and the solution used to mix it were refrigerated, bring both to room temperature before combining. After adding the solution to the powder, gently swirl the mixture to completely dissolve the powder. Do not shake. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.

Check your heartbeat during treatment. If your heart starts to beat faster, give this medication more slowly or briefly stop the infusion until your heart rate returns to normal. Ask your doctor for details on how fast to infuse your dose.

The dosage is based on your medical condition, weight, blood test results, and response to treatment.

Tell your doctor right away if your bleeding does not stop or if this medication stops working well.