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Omega-6 Fatty AcidsFind Products

Also indexed as:Safflower Oil, Sunflower Oil, Arachidonic Acid
Omega-6 Fatty Acids: Main Image

Interactions with Supplements, Foods, & Other Compounds

Linoleic acid competes with alpha-linolenic acid, an omega-3 fatty acid, for enzymes that convert simple polyunsaturated fatty acids into more complex ones. Since complex omega-3 fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are associated with heart disease prevention, reduced inflammation, and other health benefits, some authorities have argued that the high amounts of linoleic acid in the typical Western diet are detrimental to health because they can reduce the body’s production of EPA and DHA.6 While most controlled research suggests that dietary linoleic acid has some influence on the production of EPA in the body,7, 8, 9 conversion of alpha-linolenic acid into more complex omega-3 fatty acids is limited for other reasons,10, 11, 12 so that achieving adequate levels of EPA and DHA depends mostly on consuming oily fish and fish oils, which are good sources of these complex omega-3 fatty acids.13 Furthermore, higher dietary intake or high body levels of omega-6 fatty acids, most of which is linoleic acid, has been associated with reduced coronary heart disease risk in numerous preliminary studies, and with no effect on other diseases such as stroke or cancer.14

A diet high in polyunsaturated fats such as the omega-6 fatty acids increases vitamin E requirements. Based on available evidence, at least 0.6 mg (0.9 IU) of vitamin E is needed for every gram of polyunsaturated fat consumed.15

Interactions with Medicines

Certain medicines interact with this supplement.

Types of interactions:beneficial= Beneficialadverse= Adversecheck= Check
dnicon_BeneficialReplenish Depleted Nutrients


dnicon_BeneficialReduce Side Effects


dnicon_BeneficialSupport Medicine
dnicon_AvoidReduces Effectiveness


dnicon_AvoidPotential Negative Interaction


dnicon_CheckExplanation Required


The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, click a medicine and click through to "More about" or refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.