This medication is given slowly, usually over 1 hour, into a vein as directed by your doctor, usually every 2 weeks. Your dose and how often it is given depends on your weight, medical condition, and response to treatment.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Do not shake the solution. It may contain a few white particles. Before using, check this product visually for other particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Velaglucerase may rarely cause side effects (such as headache, dizziness, fainting, weakness/tiredness, nausea, high fever) while it is being given. Your doctor may decide to temporarily stop or slow down the medication infusion if this happens. Tell your healthcare professional right away if you have any of these symptoms during your treatment. Your doctor may direct you to take other medications (such as antihistamines, drugs for fever, or corticosteroids such as prednisone) before your treatment to prevent these reactions from happening again.

Tell your doctor if your condition lasts or gets worse. Blood, liver, and spleen problems usually improve in the first year of treatment. It may take 2 to 3 years of treatment to see the full benefit to your bones.