Progesterone
Progesterone is a hormone from a corpus luteum, formed by the cyclical rupture of an ovarian follicle. Progesterone is necessary for proper uterine and breast development and function.
- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
This supplement has been used in connection with the following health conditions:
| Used for | Amount | Why |
|---|---|---|
Amenorrhea | Consult a qualified healthcare practitioner |  [2 stars] The oral, micronized form has been shown to successfully induce normal menstrual bleeding in women with secondary amenorrhea. (Use of this natural hormone should always be supervised by a doctor.) |
Menopause | Apply enough topical cream to provide 20 mg of the supplement to the skin daily | [2 stars] Progesterone, either natural or synthetic, has been linked to improved hot flashes, anxiety, depression, sleep problems, and sexual functioning, and quality of life. |
Osteoporosis | Consult a qualified healthcare practitioner | [2 stars] Preliminary evidence suggests that progesterone might reduce osteoporosis risk by promoting bone density. |
Dysmenorrhea | Refer to label instructions |  [1 star] Some practitioners report success using topical progesterone cream for dysmenorrhea. |
Premenstrual Syndrome | Refer to label instructions | [1 star] Anecdotal reports suggest that progesterone may be effective against PMS symptoms. |
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.