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Also indexed as:Piper methysticum
Kava: Main Image© Steven Foster
Botanical names:
Piper methysticum

Interactions with Supplements, Foods, & Other Compounds

Caution: Aside from the reported interactions, kava inhibits a number of the cytochrome P450 enzymes that play a role in the breakdown of many medications.14 Therefore, kava has the potential to interact with a wide range of medications, even if such interactions have not yet been reported. Individuals taking any medication who wish to use kava should check with their physician or pharmacist to determine whether inhibiting cytochrome P450 could cause an adverse drug interaction.

Kava should not be taken together with other substances that also act on the central nervous system, such as alcohol, barbiturates, antidepressants, and antipsychotic drugs. One study found that large amounts of a traditional kava preparation did worsen cognitive impairment caused by alcohol consumption.15 However, at the amounts recommended above, kava does not appear to impair cognitive performance. Kava has also been reported to cause excessive sedation and grogginess when combined with benzodiazepines.16 One study found it was safe to drive after taking kava at the amounts listed above.17 However, the German Commission E monograph states that kava, when taken at the recommended levels, may adversely affect a person’s ability to safely drive or operate heavy machinery.18

Interactions with Medicines

Certain medicines interact with this supplement.

Types of interactions:beneficial= Beneficialadverse= Adversecheck= Check
dnicon_BeneficialReplenish Depleted Nutrients

none

dnicon_BeneficialReduce Side Effects

none

dnicon_BeneficialSupport Medicine

none

dnicon_AvoidReduces Effectiveness

none

dnicon_AvoidPotential Negative Interaction
dnicon_CheckExplanation Required

none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, click a medicine and click through to "More about" or refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.